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Technetiumm (99m Tc) is a metastable nuclear isomer of technetium (itself an isotope of technetium), symbolized as 99m Tc, that is used in tens of millions of medical diagnostic procedures annually, making it the most commonly used medical radioisotope in the world.. Technetiumm is used as a radioactive tracer and can be detected in the body by medical equipment (gamma cameras). Nov 22,  · Technitium MAC Address Changer is a freeware Mac changer software download filed under network software and made available by Technitium for Windows.. The review for Technitium MAC Address Changer has not been completed yet, but it was tested by an editor here on a PC and a list of features has been compiled; see below. Technitium is an independent software developer created and managed by Shreyas Zare who develops software part-time as a hobby.

 

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Jun 07,  · Technetium (chemical symbol Tc) is a silver-gray, radioactive metal. It occurs naturally in very small amounts in the earth’s crust, but is primarily man-made. Technetiumm is a short-lived form of Tc that is used as a medical diagnostic tool. Dec 09,  · TMAC Technitium MAC Address Changer is one of the most popular File Transfer and Networking alongside Packet Tracer, DNS Jumper, and Remote Install. This app has its advantages compared to other File Transfer and Networking applications. TMAC Technitium MAC Address Changer is lightweight and easy to use, simple for beginners and powerful for professionals. Nov 22,  · Technitium MAC Address Changer is a freeware Mac changer software download filed under network software and made available by Technitium for Windows.. The review for Technitium MAC Address Changer has not been completed yet, but it was tested by an editor here on a PC and a list of features has been compiled; see below.
 
 
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Technetiumm 99m Tc is a metastable nuclear isomer of technetium itself an isotope of technetium , symbolized as 99m Tc, that is used in tens of millions of medical diagnostic procedures annually, making it the most commonly used medical radioisotope in the world. Technetiumm is used as a radioactive tracer and can be detected in the body by medical equipment gamma cameras.

It is well suited to the role, because it emits readily detectable gamma rays with a photon energy of keV these 8. The relatively “short” physical half-life of the isotope and its biological half-life of 1 day in terms of human activity and metabolism allows for scanning procedures which collect data rapidly but keep total patient radiation exposure low. The same characteristics make the isotope unsuitable for therapeutic use. Technetiumm was discovered as a product of cyclotron bombardment of molybdenum.

This procedure produced molybdenum , a radionuclide with a longer half-life 2. This longer decay time allows for 99 Mo to be shipped to medical facilities, where 99m Tc is extracted from the sample as it is produced. In turn, 99 Mo is usually created commercially by fission of highly enriched uranium in a small number of research and material testing nuclear reactors in several countries.

Seaborg isolated for the first time the metastable isotope technetiumm, after bombarding natural molybdenum with 8 MeV deuterons in the inch mm cyclotron of Ernest Orlando Lawrence ‘s Radiation laboratory. This was a form of radioactive decay which had never been observed before this time. This chain of decay was later shown to have the mass number 99, and While Richards was in charge of the radioisotope production at the Hot Lab Division of the Brookhaven National Laboratory , Walter Tucker and Margaret Greene were working on how to improve the separation process purity of the short-lived eluted daughter product iodine from its parent, tellurium with a half life of 3.

Based on the similarities between the chemistry of the tellurium-iodine parent-daughter pair, Tucker and Greene developed the first technetiumm generator in The first US publication to report on medical scanning of 99m Tc appeared in August After build-up of 99m Tc, they could visualize the liver using the keV gamma ray emission.

The production and medical use of 99m Tc rapidly expanded across the world in the s, benefiting from the development and continuous improvements of the gamma cameras. Between and , numerous scientific studies demonstrated the use of 99m Tc as radiotracer or diagnostic tool. Production and distribution of 99m Tc generators were transferred to private companies. At the end of the s, , Ci 7. However, in , Cintichem detected an underground leak of radioactive products that led to the reactor shutdown and decommissioning, putting an end to the commercial production of 99 Mo in the USA.

The production of 99 Mo started in Canada in the early s and was shifted to the NRU reactor in the mid s. However, problems with the MAPLE 1 reactor, most notably a positive power co-efficient of reactivity , led to the cancellation of the project in In , the first 99m Tc procedures were carried out in Auckland , New Zealand. In May , Scheer and Maier-Borst were the first to introduce the use of 99m Tc for medical applications. Global shortages of technetiumm emerged in the late s because two aging nuclear reactors NRU and HFR that provided about two-thirds of the world’s supply of molybdenum, which itself has a half-life of only 66 hours, were shut down repeatedly for extended maintenance periods.

After the observation of gas bubble jets released from one of the deformations of primary cooling water circuits in August , the HFR reactor was stopped for a thorough safety investigation. NRG received in February a temporary license to operate HFR only when necessary for medical radioisotope production.

HFR stopped for repairs at the beginning of and was restarted in September Two replacement Canadian reactors see MAPLE Reactor constructed in the s were closed before beginning operation, for safety reasons. Technetiumm is a metastable nuclear isomer , as indicated by the “m” after its mass number This means it is a decay product whose nucleus remains in an excited state that lasts much longer than is typical.

The nucleus will eventually relax i. Both of these decay modes rearrange the nucleons without transmuting the technetium into another element. These are the radiations that are picked up by a gamma camera when 99m Tc is used as a radioactive tracer for medical imaging. These conversion electrons will ionize the surrounding matter like beta radiation electrons would do, contributing along with the Pure gamma emission is the desirable decay mode for medical imaging because other particles deposit more energy in the patient body radiation dose than in the camera.

Metastable isomeric transition is the only nuclear decay mode that approaches pure gamma emission. This is still a short half-life relative to many other known modes of radioactive decay and it is in the middle of the range of half lives for radiopharmaceuticals used for medical imaging. After gamma emission or internal conversion, the resulting ground-state technetium then decays with a half-life of , years to stable ruthenium This process emits soft beta radiation without a gamma.

Such low radioactivity from the daughter product s is a desirable feature for radiopharmaceuticals. The parent nuclide of 99m Tc, 99 Mo, is mainly extracted for medical purposes from the fission products created in neutron-irradiated U targets, the majority of which is produced in five nuclear research reactors around the world using highly enriched uranium HEU targets.

Production of 99 Mo by neutron activation of natural molybdenum, or molybdenum enriched in 98 Mo, [46] is another, currently smaller, route of production. The feasibility of 99m Tc production with the MeV-proton bombardment of a Mo target in medical cyclotrons was demonstrated in A particular drawback of cyclotron production via p,2n on Mo is the significant co-production of ground-state 99 Tc.

The preferential in-growth of this nuclide occurs due to the larger reaction cross-section pathway leading to the ground state, which is almost five times higher at the cross-section maximum in comparison with the metastable one at the same energy.

Liquid metal molybdenum-containing targets have been proposed that would aide in streamlined processing. Other particle accelerator-based isotope production techniques have been investigated. The supply disruptions of 99 Mo in the late s and the ageing of the producing nuclear reactors forced the industry to look into alternative methods of production.

Technetiumm’s short half-life of 6 hours makes storage impossible and would make transport very expensive. Instead, its parent nuclide 99 Mo is supplied to hospitals after its extraction from the neutron-irradiated uranium targets and its purification in dedicated processing facilities. The generators, colloquially known as a moly cows, are devices designed to provide radiation shielding for transport and to minimize the extraction work done at the medical facility.

Molybdenum spontaneously decays to excited states of 99 Tc through beta decay. At the hospital, the 99m Tc that forms through 99 Mo decay is chemically extracted from the technetiumm generator. One technetiumm generator, holding only a few micrograms of 99 Mo, can potentially diagnose 10, patients [ citation needed ] because it will be producing 99m Tc strongly for over a week. This is directly suitable for medical applications only in bone scans it is taken up by osteoblasts and some thyroid scans it is taken up in place of iodine by normal thyroid tissues.

Secondly, a ligand is added to form a coordination complex. The ligand is chosen to have an affinity for the specific organ to be targeted. Other ligands include sestamibi for myocardial perfusion imaging and mercapto acetyl triglycine for MAG3 scan to measure renal function. In , Eckelman and Richards presented the first “kit” containing all the ingredients required to release the 99m Tc, “milked” from the generator, in the chemical form to be administered to the patient. Technetiumm is used in 20 million diagnostic nuclear medical procedures every year.

Klaus Schwochau’s book Technetium lists 31 radiopharmaceuticals based on 99m Tc for imaging and functional studies of the brain , myocardium , thyroid , lungs , liver , gallbladder , kidneys , skeleton , blood , and tumors. Depending on the procedure, the 99m Tc is tagged or bound to a pharmaceutical that transports it to its required location. For example, when 99m Tc is chemically bound to exametazime HMPAO , the drug is able to cross the blood—brain barrier and flow through the vessels in the brain for cerebral blood-flow imaging.

This combination is also used for labeling white blood cells 99m Tc labeled WBC to visualize sites of infection. Imaging to measure renal function is done by attaching 99m Tc to mercaptoacetyl triglycine MAG3 ; this procedure is known as a MAG3 scan.

Technetiumm can be readily detected in the body by medical equipment because it emits The “short” physical half-life of the isotope and its biological half-life of 1 day in terms of human activity and metabolism allows for scanning procedures which collect data rapidly, but keep total patient radiation exposure low.

Diagnostic treatment involving technetiumm will result in radiation exposure to technicians, patients, and passers-by. A spouse who stays constantly by the side of the patient through this time might receive one thousandth of patient’s radiation dose this way.

The short half-life of the isotope allows for scanning procedures that collect data rapidly. The isotope is also of a very low energy level for a gamma emitter. The energy of gammas from 99m Tc is about the same as the radiation from a commercial diagnostic X-ray machine, although the number of gammas emitted results in radiation doses more comparable to X-ray studies like computed tomography.

Technetiumm has several features that make it safer than other possible isotopes. Its gamma decay mode can be easily detected by a camera, allowing the use of smaller quantities. And because technetiumm has a short half-life, its quick decay into the far less radioactive technetium results in relatively low total radiation dose to the patient per unit of initial activity after administration, as compared with other radioisotopes.

In the form administered in these medical tests usually pertechnetate , technetiumm and technetium are eliminated from the body within a few days. Single photon emission computed tomography SPECT is a nuclear medicine imaging technique using gamma rays. It may be used with any gamma-emitting isotope, including 99m Tc. In the use of technetiumm, the radioisotope is administered to the patient and the escaping gamma rays are incident upon a moving gamma camera which computes and processes the image.

Projections are acquired at defined points during the rotation, typically every three to six degrees. The time taken to obtain each projection is also variable, but 15—20 seconds are typical. This gives a total scan time of 15—20 minutes. The technetiumm radioisotope is used predominantly in bone and brain scans. For bone scans , the pertechnetate ion is used directly, as it is taken up by osteoblasts attempting to heal a skeletal injury, or in some cases as a reaction of these cells to a tumor either primary or metastatic in the bone.

In brain scanning, 99m Tc is attached to the chelating agent HMPAO to create technetium 99m Tc exametazime , an agent which localizes in the brain according to region blood flow, making it useful for the detection of stroke and dementing illnesses that decrease regional brain flow and metabolism. These employ the same radioligands and have the same uses as SPECT scanning, but are able to provide even finer 3-D localization of high-uptake tissues, in cases where finer resolution is needed.

The nuclear medicine technique commonly called the bone scan usually uses 99m Tc. It is not to be confused with the “bone density scan”, DEXA , which is a low-exposure X-ray test measuring bone density to look for osteoporosis and other diseases where bones lose mass without rebuilding activity. The nuclear medicine technique is sensitive to areas of unusual bone rebuilding activity, since the radiopharmaceutical is taken up by osteoblast cells which build bone.

The technique therefore is sensitive to fractures and bone reaction to bone tumors, including metastases. For a bone scan, the patient is injected with a small amount of radioactive material, such as —1, MBq 19—30 mCi of 99m Tc-medronic acid and then scanned with a gamma camera.

Medronic acid is a phosphate derivative which can exchange places with bone phosphate in regions of active bone growth, so anchoring the radioisotope to that specific region. To view small lesions less than 1 centimetre 0. Myocardial perfusion imaging MPI is a form of functional cardiac imaging, used for the diagnosis of ischemic heart disease.

The underlying principle is, under conditions of stress, diseased myocardium receives less blood flow than normal myocardium. MPI is one of several types of cardiac stress test.

As a nuclear stress test the average radiation exposure is 9.